DMSO: Safety, Handling, & Recipes


DMSO is an abbreviation for Dimethyl Sulfoxide and it is a 100% natural substance. Every tree has Dimethyl Sulfoxide in it and the substance is extracted by paper industry. It is a colorless liquid which freezes at the temperature of 68 F. When applied to the skin Dimethyl Sulfoxide penetrates deep into tissues and will carry anything applied together into the bloodstream in seconds (which makes it poweful!).dmso Dimethyl Sulfoxide

DMSO is rich in sulfur and sulfur is a major building block of collagen. Billions of people worldwide have used DMSO for pain relief, stroke, toothaches, acne, head injuries, headaches, burns, hemorrhoids, treating scars, arthritis, and for many other ailments. It has been documented as a safe substance for long-term use, however it is not approved for medical use in the USA and sold as a solvent only. You can read more about Dimethyl Sulfoxide here.

The below information is for research purposes only and not intended to diagnose or cure any disease.

DMSO (Dimethyl Sulfoxide): how to use, safety and handling

Dimethyl Sulfoxide is a 100% natural product which is documented as a safe substance. However, some precautions are needed when using it. It may irritate and wrinkle the skin if handled improperly. It carries different kinds of molecules through the skin when applied together. This means you need to handle dimethylsulfoxide with care using clean instruments and tools, pay attention to the substances you apply to the skin together with dimethylsulfoxide. DMSO is non-toxic and 7 times safer than aspirin.

Here are general safety rules about handling dimethylsulfoxide:

  • Do NOT use DMSO when pregnant, planning pregnancy or nursing.
  • Eye damage in laboratory animals has not been confirmed, however avoid contact with eyes to be on a safe side.
  • Dilute it with distilled water prior to use. 50%-70% dilution is often suggested. Fair-skinned people should use precautions with the strength they use as they are more prone to skin irritations. It is best to begin with 50% dilution.
  • These containers are safe to use with dimethylsulfoxide: glass, stainless steel, wooden, ceramic and rigid plastic in the form of spray bottles. A rigid-plastic is a hard plastic which exhibits no elastic deformation. It is best to buy DMSO in a glass bottle.
  • When DMSO is applied to skin and is still wet do not come in contact with any substance or clothing. Let it penetrate and dry for about 20 minutes.
  • Use gloves when applying DMSO to skin to avoid temporary skin wrinkling on the palm. Soak the tip of your glove in DMSO for 24 hours and see if any damage occurred. If there is no damage, you can use those gloves to apply DMSO on your skin.
  • Use clean or sterile bottles and mixing equipment.
  • Temporar skin irritation, redness, itching, wrinkling of the palm may occur when not diluted properly. These kind of irritations disappear within hours. Wrinkling will disappear within a few days (which can be avoided by proper dilution and using gloves as stated above).
  • A very few people with weak liver may react to DMSO. First, test for DMSO allergy by rubbing a drop of DMSO to clean and dried arm allowing to soak for 15 minutes. Watch for pain in liver for the next 24 hours. If you have a pain in liver area avoid using DMSO and improve liver function before using it. Cleanse your liver and retest for DMSO allergy. If there is no pain, then DMSO is safe to use.
  • If using bare hands to apply, do not wear a nail polish.
  • You can wear a plastic bag (sandwich bag) to apply DMSO to skin. Test the plastic bag first same as testing gloves described above.
  • Use chemical-free soap to wash application areas and hands before applying DMSO.
  • Dimethyl Sulfoxide is non-reactive to these types of plastic: PETE (1), HDPE (2), LDPE (4), PP (5), Nylon, PTFE.

Recipes with DMSO: how to dilute and how to mix

I collected all the recipes below from different sources like reviews, books, articles, blogs. I did not test them on myself so I don’t know if they work or not. This information is for research purposes only and not intended to treat or prevent diseases. The list will be updated periodically.

  1. Pain relief (joint pain, arthritis, strains, and others). Mix organic Castor oil with Dimethyl Sulfoxide in 1:1 ratio. Make sure that hands and the skin are clean before applying the mixture. Apply a few times a week or as needed.
  2. Spinal Stenosis Pain Relief. Mix Dimethyl Sulfoxide with distilled water in 2:1 ration. Make sure that hands and the skin are clean before applying the mixture. Apply to the painful area with clean cotton cloth. Rub for 5 minutes, re-wet the cloth 2-3 times with the solution. It may itch for 3-5 minutes.
  3. Antibiotics for cuts and scrapes. Mix Dimethyl Sulfoxide with Iodine or Iodide in 1:1 ratio.
  4. DMSO Lotion. Mix 1 oz of Dimethyl Sulfoxide with 3 oz Aloe vera gel.
  5. 1M DMSO solution recipe. Mix 8.6 ml of Dimethyl Sulfoxide with 91.4 ml of distilled water.
  6. DMSO in roller bottle. Mix Dimethyl Sulfoxide and a pure organic carrier oil in a glass roller bottle.
  7. 50% DMSO solution. Mix distilled water with Dimethyl Sulfoxide in 1:1 ratio and add a small amount of MSM.
  8. Acne treatment. Mix Dimethyl Sulfoxide with Aloe vera juice (or distilled water) in 7:3 ratio. Use as a spot treatment.
  9. Broken toe. Immediately apply Dimethyl Sulfoxide and do it so every hour. Mix DMSO with magnesium oil and apply that too.
  10. Muscle pain relief. Mix 1 oz of Dimethyl Sulfoxide and about 3 oz of aloe vera or jojoba oil in a spray bottle. Add couple of drops of organic peppermint essential oil and menthol. Spray on stiff muscles for instant relief. Make sure your skin is clean before spraying.
  11. Bruises and swelling. Apply diluted (or 90%) Dimethyl Sulfoxide to the affected area quickly and the swelling goes down in minutes and may help with bruising in couple days (or even overnight). Apply 2-4 times a day.
  12. Poison Ivy blisters. Apply diluted Dimethyl Sulfoxide on the affected area. Most of the blisters be gone in a few days (or overnight).
  13. Burns. Apply a %50-%100 solution quickly to the affected area to ease the pain and diminish scarring.
  14. Intense headache. Apply to clean forehead and temples for a fast relief. Use diluted (%30-%50 DMSO mixed with 70%-%50 distilled water). Use clean fingers to apply. Due to Ogden (1967) a 90% solution is more effective, which may give burning sensation for several minutes.
  15. Toe nail fungus. Use it with pure tea tree oil.
  16. Raised scar. Use %50-%80 diluted Dimethyl Sulfoxide 2-3 times a day.
  17. Inflamed lymph node. Apply 50% diluted solution.
  18. Varicose veins. Apply diluted solution to the affected area. Make sure the skin is clean.
  19. DMSO solution with less side-effects (for less body odor, itching, bad breath, etc). Mix it with magnesium chloride solution and/or organic raw honey.
  20. Hemorroids. Apply a 70% solution to the affected area for quick pain relief.
  21. Bee/wasp stings. Immediately apply to the affected area to stop the pain.


  3. Heal Yourself At Home




Hi! My name is Feruza. I am from sunny Uzbekistan. Currently, I am a stay at home mom of two beautiful boys and have a wonderful supportive husband. I hold Masters' degree in Multimedia Engineering, but at this moment, I am just a Mom. With all my love to my family, I try to nourish them with wholesome foods always trying and experimenting new recipes. My hobbies are languages, healthy lifestyle, nourishing food, books, sewing, knitting, DIYs, homeschooling, and much more! I felt the need of my own corner where I could collect all of my favorite recipes and information without losing them. And here it is! Enjoy!


  1. My dog has had ulcérations/calcifications on his skin from prolonged use of Prednisone.

    What may I use to soften these up?

    • Hi, Julia! I am sorry for your dog and hope he heals and gets better soon. I am afraid I cannot be helpful in this matter. I would not use DMSO for open wounds and ulceration. Hope you can find a solution soon. Thank you for visiting my blog and have a nice day!

  2. Hi. Can i use stailess still with it? Thanks. To Julia. Try green clay. Another wonderfull healer. Do your own research on how to apply it.

  3. I’ve been using dmso for all types of health benefits for over five years now. I eventually found that I was growing new hair on my scalp, so I started researching, and found that it’s been used for that for quite awhile, growing new hair! But it only recovers what you lost in the past couple years. I’m still bald! lol Just with more hair now.

    Helps with looking younger, using it on my face, scalp and chest, it gets rid of liver spots and other blemishes, acne, etc… I believe that if you are careful, using it in a resoponsible way, that it can help with many ailments. Just make sure you NEVER use colored clothing over top of it right after use!

    Rather, use white, non colored clothing, and you should be fine, as it is a transfer agent of ANYTHING you put on your skin! So beware! But don’t let these people that believe everything their gov’t tells them that it’s too dangerous. I believe that DMSO can be of great value to your health, and maybe even save your life.

    But you need to do the research!

  4. You advise to use in glass, stainless steel, wooden, ceramic and rigid plastic in the form of spray bottles. My question is the straw used in spray bottles, how do I know it’s safe to use. I’ve only used a glass dropper in a glass bottles before. Thank you kindly!

    • Hi, Lindielle! I had the same question before. It is not easy to find out the plastic type of the spray straw, but I assume it is a rigid plastic. Rigid plastic is hard and cannot be easily scratched in my understanding. I avoid using any plastic with DMSO anyway. Glass bottle with glass dropper sounds safe, however not easy to apply. I myself use glass roller with stainless rolling ball which still has a hard plastic attached to the stainless moving ball. I do try to keep it upright to minimize contact with plastic. I think it is much easier to use a roller bottle to apply DMSO than using a dropper or a spray.

  5. where do you get glass stainless ball bottles and how do you fill them?

  6. Hi! I just purchased some nearly pure DMSO. I wish to make an anti cancer ointment, with capsaicin, garlic, ginger, aloe, and marijuana. Any suggestions on the concentration of DMSO? Thank You! You may email me any suggestions!

  7. Thanks for sharing this informative post!
    I am using DMSO liquid for my joint pain. I will keep in mind all suggestions when I will use this product.

  8. I have been exploring mixing DMSO with oils for topical use, but I have found that it does not mix well with them – even oils regarded as relatively polar. Within 5 to 30 minutes the DMSO has begun to settle on the bottom, depending on the oil and the dilution. DMSO is miscible with castor oil, but that is the only oil I’ve found that it does that with. Regarding using DMSO for pain relief, I learned that it is miscible with methyl salicylate, which is the primary pain relieving constituent in wintergreen essential oil; it should be possible to mix DMSO with wintergreen oil to boost both the pain relieving effects and the transdermal absorption rate.

  9. I just started using DMSO in the roller bottle 70% and 30% aloe for my knee joints and I wash the area with the dove unscented soap and water. You mentioned a chemical free soap where do I find that? And thank you for answering the questions were all wondering about

  10. I used DMSO for the first time yesterday. I need a knee replacement and have been putting it off. I don’t ant to continue taking pain meds. I made a solution of 50/50 using coconut oil and a few drops of peppermint oil. I have it in a glass rollerball. I do have to hake before use as it separates but, it is working already! I am amazed at how much less pain I am in.

  11. I’ve been searching for an answer to this question for some time now. I understand DMSO is a transferring agent, but when using it with oils or ointments what is the application process? Do you apply the oil or ointment first and the the DMSO or is it the reverse. Thanks in advance, as I’ve not found a real definitive answer.

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